Nature’s Trove SAM-e Review

Nature's Trove SAM-e Review

Nature’s Trove SAM-e Summarized


  • Relatively affordable at $17.49 per bottle/30 caplets
  • Easy to take – 1 caplet per day
  • SAMe is known to have benefits such as improving your mood and reducing joint pain


  • Uses a potentially harmful filler Titanium Dioxide
  • Not the highest quality SAM-e brand on the market
  • Missing many core ingredients for joint health and/or brain health


Nature’s Trove SAMe is a decent SAM-e supplement that doesn’t cost much and should give you benefits such as an improvement in your mood, sleep, and potentially a reduction in joint pain. SAM-e is a well-researched natural compound and is known to be safe for most people. In a small number of individuals, it can lead to side effects such as mania. However, we can’t say that it’s the best nootropic or joint supplement we’ve seen. With just one ingredient in the formula, Nature’s Trove SAM-e is missing a lot of the important ingredients like Lion’s Mane Mushroom, B-Complex Vitamins, and curcumin to name just a few. If you are just looking for a cheap SAM-e supplement, though, it could be a good option for you.

About Nature’s Trove SAM-e

Nature’s Trove SAM-e, is, as the name suggests, an S-Adenosyl-Methionine (SAM-e) supplement. The key active compound SAM-e has been used for almost 50 years and is studied for its effects on mood, liver health, and joint function.

Your body naturally makes some SAM-e; but things like aging, diet and environmental factors could deplete your SAM-e levels. Nature’s Trove SAM-e is intended to replenish your SAM-e levels and support beneficial mood, joint health, and liver function along the process.

But does it actually work as advertised? And how does it compare to other joint & brain supplements in terms of quality, safety, and value for money? Let’s have a closer look.

What’s Inside?

Nature's Trove SAM-e Ingredients

The only active ingredient in Nature’s Trove SAM-e, is, you’ve guessed it: SAM-e.

More precisely, it contains 400mg of the active ingredient (derived from 800mg of SAMe Tosylate Disulfate).

Here’s a look at the label.

So, what exactly is SAM-e, how does it work, and what do studies say about it?

  • SAM-e stands for S-adenosylmethionine and its primary function is to break down molecules that can’t be broken down by your body.

A completely natural supplement, SAM-e is known for aiding the synthesis of proteins and regulating metabolism in your body – especially the liver. It is often used for those who have depression, osteoarthritis, and liver disease but it has been found to be beneficial for those suffering from other conditions like Alzheimer’s and fibromyalgia too.

A study published in The Journal of Clinical Psychiatry found that taking SAM-e significantly reduced depressive symptoms as well as improving sleep quality, which could have led to better cognitive functioning. SAM-e could also be beneficial for joint health. Research shows that it can help your joints by supporting cartilage and improving overall joint health. 

While side effects from using SAM-e are not common, many studies have a small number of participants who experience “mania” after taking SAMe. Again, this is not common, but it does appear to be linked to SAM-e supplementation for reasons currently unknown to researchers. Interestingly enough, the mania-inducing side effects of SAM-e have been seen in both people with and without a history of mania. (source:

While it’s not a dangerous compound – cessation of use stops the side effects – we still don’t think SAM-e is the best nootropic/joint health supplement when compared to other well-researched compounds on the market when it comes to benefit/risk ratio.

Our Thoughts on the Ingredients in Nature’s Trove SAM-e

Even if you disregard SAM-e’s potential for causing negative side effects, it’s far from the best mood-boosting or joint health-promoting compound out there.

As we mentioned, there are many better-studied ingredients out there that could’ve been added to this supplement to increase its effectiveness.

If your goal is to promote brain health and mood, you should look for ingredients such as Phosphatidylserine, B Complex Vitamins, Citicoline, Lion’s Mane Mushroom, and Rhodiola Rosea to name a few.

If you want to get rid of joint pain and inflammation while supporting long-term cartilage health, you will want to look into selenium, MSM, glucosamine+chondroitin, curcumin, and bromelain amongst others. These are all ingredients that are generally safer and more effective than SAM-e by itself, and they work best when combined together.

This is why you’ll often see the market-leading joint and brain supplements combine these ingredients for maximum effectiveness.

Dosage Instructions (How to Take)

According to the product’s label instructions, you should take one (1) caplet of Nature’s Trove SAM-e every day, preferably on an empty stomach. For some people, additional supplementation may yield greater benefits.

What do Others Say?

We took it to Amazon to see what customers had to say about Nature’s Trove SAM-e. Generally speaking, users seem happy with how this product works for them, and reports of side effects are rare.

Here are some of their experiences;

“I have taken samE for many many years now. I usually use another brand to help with joint pain. I purchased this brand in hopes of getting a bit better value…however after 2 weeks, I noticed my joint pain was really bad and i could hardly move. Unfortunately, I went back to my more expensive brand and luckily my pain went away. I am thinking this brand is not as pure as the one I was using (same dosage).” – Marie R.

“I tried this supplement after I ran out of my normal Ashwaganda supplement. This one seems comparable. Easy to swallow, no flavor, and you don’t have to take it often during day which is convenient. For someone seeking some sort of help, this is a good start. I did not notice any sort of lowering pain with it, but everyone is different!” – Kindle Customer

“I thought this would be a good replacement for my old SAM-e. I should have read the ingredients. Lots of things I don’t want to put in my body!! and Titanium Oxide is associated with cancer.” – Mary Ashman

What are the Negative Effects of Nature’s Trove SAM-e?

As we mentioned, SAM-e is known to induce mania in some individuals. Although rare, it is something you should speak with your doctor about before trying a SAM-e supplement, just to be on the safe side.

Cost & Value

A month’s supply of Nature’s Trove Sam-e (a 30 caplet bottle) will cost you $17.49 on the official website. Note that the price can vary depending on where you buy it – it’s also available at 3rd party sellers like Amazon.

Nature’s Trove SAM-e Review: The Bottom Line

Nature’s Trove SAM-e is a decent and affordable choice if you’re looking specifically for a SAM-e supplement.

However, in our opinion, it is far from the best brain or joint supplement on the market. There are definitely better options available – products that use multiple proven ingredients that work together to give you multiple benefits

SAM-e can only do so much on its own. That said, if you know what you’re looking for, then this could be a cheap option for you. Even among SAM-e supplements, it is not the best brand due to the fact that it uses a lot of low-quality and potentially risky fillers such as titanium dioxide.

But we can’t complain since it costs only $17.49 – for the price, that’s as good as it gets!

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