Best OTC Stress Relief Supplements in 2022

Best OTC Stress Relief Supplements

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Looking to feel calmer, with less stress and anxiety? Here are our top 3 strongest over-the-counter stress relief supplements. If you already aren’t familiar with them, so-called non-prescription stress relief supplements are designed to support your mood and mindset by reducing cortisol levels, diminishing neurotransmitters linked to anxiety, and promoting a calmer headspace with less rumination in general.

After inspecting over 20 most popular stress-relief products this year, we’ve developed a list of criteria that enables us to weed out the ineffective (and potentially risky) products from ones that are safe and 100% natural. We base our list on:

  • Fast, calming effects
  • Evidence-backed ingredient profile
  • Mental clarity
  • Improvements in outlook and positivity
  • Healthy focus and ability to get out of the negative thought loop
  • Long-term safety
  • Company reputation

The following non-prescription stress relief supplements also have the ability to improve your mental and physical recovery by enhancing your sleep, which will have a positive knock-on effect on other areas of your life.

We’ve compared the best and the most popular supplements against each other, in order to see which is the best value. As a result of our search, we were able to present the 3 most effective natural stress relief products on sale right now.


• 100% natural & transparent

• Researched and fact-checked by doctors

• Relieves stress & anxiety

• Supports recovery from burnout

• Clinically dosed herbal medicines inside

• Bulk-buy deals
• Website:


• For women 30+

• Made with science-backed ingredients
• Improves stress response
• Enhances libido & mood
• Healthy for everyday use

• Website:


• 4 generously dosed nootropics

• Works to enhance all aspects of brain function
• Uses patented nutrition technologies

• Made by a well-known company, Opti-Nutra
• Website:

The Best OTC Stress Relief Supplements of 2022

Let’s look closer at our current top 3 supplements to improve your body’s stress response and enhance your overall well-being.

  • #1 Best Overall Over the Counter Stress Relief Product: SRS – The Stress Reduction Supplement
  • #2 Best for Female Vitality – Kurapeak
  • #3 Best for Cognitive Performance – Performance Lab Mind

1. SRS – The Stress Reduction Supplement

Our number one choice is SRS, an all-natural stress relief product. It is backed by the latest studies and consists of some of the best herbal remedies in healthy and effective dosages. SRS works to undo the damage done by daily stress and improve your adrenal function. SRS also tackles other symptoms associated with chronic stress, such as poor sleep and lack of energy. It helps you recover faster, focus better, and refocus when your mind wanders off.

The Stress Reduction Supplement easily stands on its own as #1 in our list. Why is it so effective for stress and anxiety, you may ask? The answer lies in its composition, which includes amino acids, plant extracts, and nutrients that are all clinically dosed to make you feel better.

Key Ingredients in SRS

Ashwagandha 500 mg

Most experts – ranging from Western dietitians to Ayurvedic doctors – tend to agree that Ashwagandha is an incredible herb. Used for thousands of years for anxiety and stress relief, as well as to improve focus, concentration, and energy production in the body. Modern studies back these claims up – showing that Ashwagandha is amazing at supporting your nervous system by adapting to your body’s and mind’s needs. As an adaptogen, Ashwagandha helps lower your stress hormones such as cortisol, while simultaneously allowing your body to produce more beneficial hormones associated with healthy brain function, muscle recovery, and deep sleep among others. In one study, volunteers took 250mg of Ashwagandha for 60 days – by the end of the study, they had 30% lower cortisol levels!

Tyrosine 300 mg

Tyrosine is an amino acid and one of the building blocks of life. Stress can hinder your production of neurotransmitters such as dopamine and norepinephrine, which can make you feel overly sluggish and stressed. Tyrosine works to replenish these neurotransmitters. As a result, Tyrosine undoes some of the damage done by stress, helping you to maintain peak cognitive function when you need it the most. A systematic study review found reliable evidence that Tyrosine supplementation improves mental functioning in stressful or challenging situations.

Serinaide (Phosphatidyserine) 100 mg

Phosphatidylserine (PS) is a fatty molecule found in your brain cell membranes. Studies show PS can directly reduce stress, which leads to an improvement in your cognitive function, attention, and information recall.

Magnesium Glycinate 150 mg

Magnesium is an important mineral that governs everything from muscle contractions, to the production of hormones that keep you calm and healthy. The problem? Far too many people are magnesium deficient. Unfortunately, most supplements use cheap forms of magnesium which don’t absorb well, so you can’t expect a reduction in anxiety or stress from those. Luckily, SRS uses magnesium glycinate which is one of the most bioavailable forms of the mineral.

Taurine 500 mg 

Taurine is a natural amino acid with important role in sleep, energy management, and mood regulation. It works by affecting your GABA receptors.

Gamma-aminobutyric acid (GABA) is a crucial neurotransmitter that makes you feel calm and sleepy – it gets released before you go to bed. Things like beer can boost your GABA, too. However, there are also things that lower your GABA levels, such as stress, injury, and chronic inflammation. So, isn’t it best to supplement with GABA directly? Not really! GABA supplements tend to be ineffective because GABA itself has large molecular structure, being unable to pass the blood-brain barrier easily. As such, supplementing with GABA precursors – such as taurine – leads to better absorption and increased GABA production in the brain.

Zinc 10 mg

Zinc is vital for a healthy nervous system, and by extension, your stress response. Prolonged stress and inflammation drain your body of zinc. Because of this, supplementation is an excellent way to return to optimal well-being after chronic stress. Research shows that zinc supplements help to re-stabilize cortisol levels.

Chamomile Extract 100 mg

Chamomile is another powerful “cortisol-buster”. It works by directly lowering your stress levels. Compounds in the plant also help promote restful and restorative sleep by binding to your benzodiazepine brain receptors.


BioPerine® is a patented form of black pepper extract that contains 95% piperine. Piperine is the bioactive compound of black pepper that increases absorption of other ingredients, so you can get the most out of them. Compare this with regular black pepper in your kitchen, which only has 5% piperine, making it ineffective.

Pros and Cons of SRS – The Stress Reduction Supplement


  • Science-backed formula
  • A synergistic blend of plants and nutrients that combat the effects of chronic stress
  • Bolsters your physical and mental stress response, improves sleep, enhances recovery, and improves focus.


  • Only available on the manufacturer’s website.

SRS is Available at

Click Here to Check Price

2. Kurapeak – Best Supplement for Women

Kurapeak is a vitality supplement for women. They have a similar product developed for men – Centrapeak.

Kurapeak has been made to help women with their health, work, and home life. It works by improving your libido, energy levels, and focus. At the same time, Kurapeak’s high-quality ingredients reduce the detriments of stress and anxiety on your body and mind.


You no longer have to travel half the world to benefit from various herbal medicines and plants. Today, you can get all the best plants such as Ginseng from across the world. Kurapeak contains only the most researched and safest ancient medicines.

The ingredients include Panax Ginseng, Pine Bark Extract, Maca, L-Theanine, Rhodiola Rosea, Turmeric, and the most expensive spice in the world – Saffron.

Here we’ll look closer at a few of the ingredients. If you want to see the full breakown of the studies and academic research in each Kurapeak ingredient, you can visit their website:

Rhodiola Rosea – 100mg

Rhodiola Rosea is an adaptogen that’s been shown to bolster the stress response. It’s been used for hundreds of years to tackle fatigue, stress, and anxiety among others.

Turmeric Curcumin 50:1 200mg

Turmeric can boost dopamine and serotonin, two key neurotransmitters involved in mood and stress regulation. The active ingredients in turmeric, curcuminoids, are the ones to thank. However, the Turmeric found in your kitchen only has around 5% curcuminoids which means you’d have to eat a ton to experience the benefits. The turmeric in Kurapeak, by contrast, is standardized to have 95% curcuminoids.

A randomized controlled trial showed that depressed people who took curcumin experienced similar improvements in their depression symptoms as with Prozac! The study showed that taking Prozac and curcumin together worked even better.

Panax Ginseng – 120 mg

Ginseng is an adaptogen with a history of use dating over 5,000 years back. It boosts your energy, mental sharpness, and enhances sex drive to improve overall well-being. Latest studies confirm Ginseng’s benefits in terms of strengthening your nervous system, which translates to an improved ability to deal with stress and anxiety.

Pros and Cons


  • Designed specifically for females.
  • Formula is evidence-supported
  • Contributes to a reduction in mental tension and fatigue
  • Boosts energy


  • Lacks some basic vitamins and minerals.
  • You can only buy it on the manufacturer’s website.

3. Performance Lab Mind

Performance Lab (Opti-Nutra) is a respected nutrition company from the U.K. They use advanced, patented technologies to develop some of the cleanest-quality supplements on the market.

Mind is a nootropic/brain supplement that is designed to naturally elevate your cognitive performance. At first glance, its 4-ingredient formula may look simple. However, the quality and dosages of the ingredients used in Mind far outperform most supplements on offer today.

Case in point: almost all the ingredients in Performance Lab Mind come in patented versions, standardized to have a precise amount of active compounds for maximum effect on your brain function.

We’ve already mentioned two ingredients in Mind under SRS: Phosphatidylserine (100mg) and Tyrosine (250mg). In addition to these two, Mind also contains:

Citicoline (Cognizin) 250 mg

Cognizin is a highly bioavailable form of citicoline patented by Performance Lab. Citicoline supports brain’s circuits and the production of acetylcholine which strengthens your memory and learning and also enhances attention span. Citicoline is also neuroprotective and reduces inflammation in the brain.

Maritime Pine Bark Extract 75 mg

Native to France, bark of the French Maritime Pine tree has high amounts of antioxidants – known as proanthocyanidins – which are shown to increase blood circulation to the brain. In doing so, they promote increased brain function, brighter mood, and balanced blood pressure to name a few.

Pros and Cons of Mind


  • Streamlined formula – 4 generously dosed nootropics for healthy and safe daily use
  • Improves your learning capacity, memory retention, focus maintenance, and energy levels
  • Helps your mind to recover quickly after stress
  • Helps with symptoms linked to stress, such as mental fatigue and brain fog


  • Not specifically formulated for stress and anxiety, but all-around brain health
  • It can only be bought on the manufacturer’s website.

Anything Else to Consider?

Supplements are an excellent aid that can help lower your stress and anxiety symptoms. However, by having the right foundations – diet, exercise, relaxation time – you will naturally deal with stress better, and the effects of these supplements will be enhanced.

Here are some of the basic lifestyle habits you should stick to to ensure you get the most out of the aforementioned stress supplements:

  • Aerobic and resistance training – Exercise releases dopamine and serotonin which focus your mind, distract you from worries, and make you feel good. Even a quick walk can make a massive difference. If you can find someone to exercise with, even better.
  • Mindfulness and meditation – Mindfulness is all about being in the present moment. At first, this can be really hard, as our mind likes to wonder a lot, which keeps us stressed. Luckily, doing meditation consistently is just like any skill – it improves over time, and you start to feel more relaxed and at ease. You start to see the thoughts for what they are, and they begin to lessen in frequency and intensity.
  • Diet – What you eat fuels both your body and mind. Your gut, where over 90% of your serotonin resides, is directly connected to your brain. A diet high in processed foods can be detrimental to your gut microbiome, negatively affecting your mood in the process.
  • Sleep – This is arguably the most important item on the list. Sleep impacts everything from hormone production, energy, mood, and motivation. Lack of sleep can burn out your adrenal glands, which has the biggest impact on chronic stress. Having a healthy sleep schedule keeps your body nourished, and your mind calm.

When you add a quality stress relief supplement on top of these lifestyle habits, you will see the best results.

Conclusion on the Best Over the Counter (OTC) Supplements for Stress

So there you have it, these are currently the best-reviewed stress relief supplements for 2022.

The most effective supplement to reduce stress at the moment, in our experience, is SRS. It has most of our favorite ingredients which are clinically dosed.

Kurapeak and Mind are also great options. Kurapeak, for women – it enhances mood, well-being, and female health & vitality in general. Mind is the superior option if you’re looking for a memory and focus nootropic.

If you’re looking improved sleep, focus, and stress response, giving you the ability to make long-lasting changes in your life, our top choice remains SRS.

To finish this off with one final note: supplements are only a part of the battle. To experience the most profound change, you need to have good habits in place as well. If you’ve tried supplements and nothing helps, remember to speak to a qualified professional about other options which may be helpful for your specific situation.

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