Best OTC Stress Relief Supplements in 2022

Best OTC Stress Relief Supplements

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Looking to feel calmer, with less stress and anxiety? Here are our top 3 strongest over-the-counter stress relief supplements. If you already aren’t familiar with them, so-called non-prescription stress relief supplements are designed to support your mood and mindset by reducing cortisol levels, diminishing neurotransmitters linked to anxiety, and promoting a calmer headspace with less rumination in general.

After inspecting over 20 most popular stress-relief products this year, we’ve developed a list of criteria that enables us to weed out the ineffective (and potentially risky) products from ones that are safe and 100% natural. We base our list on:

  • Fast, calming effects
  • Evidence-backed ingredient profile
  • Mental clarity
  • Improvements in outlook and positivity
  • Healthy focus and ability to get out of the negative thought loop
  • Long-term safety
  • Company reputation

The following non-prescription stress relief supplements also have the ability to improve your mental and physical recovery by enhancing your sleep, which will have a positive knock-on effect on other areas of your life.

We’ve compared the best and the most popular supplements against each other, in order to see which is the best value. As a result of our search, we were able to present the 3 most effective natural stress relief products on sale right now.


• 100% natural & transparent

• Researched and fact-checked by doctors

• Relieves stress & anxiety

• Supports recovery from burnout

• Clinically dosed herbal medicines inside

• Bulk-buy deals
• Website:


• For women 30+

• Made with science-backed ingredients
• Improves stress response
• Enhances libido & mood
• Healthy for everyday use

• Website:


• 4 generously dosed nootropics

• Works to enhance all aspects of brain function
• Uses patented nutrition technologies

• Made by a well-known company, Opti-Nutra
• Website:

Vitamins & Minerals for Stress

Many of the best stress supplements will use a combination of proven nutrients & herbal extracts. Together, these ingredients work to enhance your body’s stress response, allowing you to better deal with everyday challenges.

Additionally, things like stress and anxiety can often be due to vitamin deficiencies. If you’re having issues with constant fatigue and tension, then it’s always best to check with your doctor for a blood test. Common deficiencies people have include vitamin D, zinc, and magnesium, which are found in our current #1 anti-stress supplement – SRS.

Vitamin B Complex

B complex includes all of the 8 essential B vitamins. They work well together to boost your mood. More specifically, vitamin B12 is linked with mood regulation. If you’re eating a strict plant-based or vegetarian diet, then supplementation of B12 is a good idea as it’s mostly found in fish and meat.

Vitamin C

Vitamin C is one of the nature’s strongest antioxidants. It is linked to a healthy nervous system and stress response. Found in high amounts in our adrenal glands, vitamin C helps your body better control cortisol levels and therefore improve your adrenal response.

Vitamin D

Vitamin D, (AKA: the sunshine vitamin, a secosteroid hormone) is famed for its ability to boost mood. Most of the vitamin D we get is from the sun, which could be part of the reason why basking in the sun makes people happier. If you don’t get enough sun, you should supplement it, as most foods are poor sources of this nutrient.


As many as 75% of people worldwide don’t get enough magnesium daily. A deficiency in this mineral is linked to anxiety and low mood. Magnesium is found in the soil from which our foods grow, but as the soil quality worldwide is depleting, we don’t get as much as we once did. As a result, supplementation will result in benefits for many people.

Omega 3

Omega 3 consists of fatty acids essential for proper brain and body function – most notably, EPA and DHA. These have been shown to enhance brain health and reduce the risk of depression. DHA, particularly, is key in the production of serotonin which helps regulate your mood. Fish are the most common source of omega-3s. However, with growing concerns around overfishing and contaminated fish in the world’s oceans, many people are turning to supplements instead. DHA can be sourced from algae, and so sustainable and vegan-friendly supplements are available too. As a matter of fact, algae is where fish get their omega-3s from, as well.

The Best OTC Stress Relief Supplements of 2022

So, now that you know what makes a good stress relief supplement, let’s have a look at our current top 3 supplements to improve your body’s stress response and enhance your overall well-being.

  • #1 Best Overall Over the Counter Stress Relief Product: SRS – The Stress Reduction Supplement
  • #2 Best for Female Vitality – Kurapeak
  • #3 Best for Cognitive Performance – Performance Lab Mind

1. SRS – The Stress Reduction Supplement

The number one stress supplement was an easy pick. SRS is an all-natural stress relief product, backed by latest studies and consisting of the best stress-busting ingredients at clinically tested dosages. It works to undo the damage done by daily stress and improve your adrenal response. SRS also tackles other common symptoms of stress. It enhances sleep and increases the body’s recovery and energy levels. In a world where distractions are at every corner, SRS will help you focus and refocus when your mind wanders off.

What makes SRS so effective at reducing stress and anxiety? It is composed of several amino acids, herbal medicines, and nutrients that have all been shown, through clinical research, to help you feel better mentally and physically.

Key Ingredients

Ashwagandha 500 mg

Whether you’re talking to an Ayurvedic doctor or a Western dietitian, most seem to agree that Ashwagandha is an amazing herb. Used for thousands of years to tame stress and anxiety, enhance focus and concentration and boost energy. And modern studies have supported these benefits time and time again.

Ashwagandha is an adaptogen. In nature, adaptogens are rare and amazing herbal medicines that support your nervous system by adapting to the needs of your body and mind. Ashwagandha is shown to work with our nervous system to reduce levels of cortisol and other stress hormones – undoing some of the damage done by chronic stress in the process. In one study, volunteers took 250mg of Ashwagandha for 60 days – by the end of the study, they had 30% lower cortisol levels!

Tyrosine 300 mg

Tyrosine is an amino acid and one of the building blocks of life. Stress can hinder the creation of certain neurotransmitters, including dopamine and norepinephrine, which can make you sluggish and overly stressed. However, Tyrosine works to naturally replenish levels of these neurotransmitters. As a result, it undoes some of the damage done by stress, helping you to maintain peak cognitive function (aka, stay cold) when things get hot. A systematic study review concluded that Tyrosine supplementation improves mental functioning in stressful or challenging situations.

Serinaide (Phosphatidyserine) 100 mg

Phosphatidylserine (PS) is a fatty acid found in cells that is vital for brain function. Research links PS supplementation with reduced stress and anxiety and improved cognitive function, recall, and attention span. PS also diminishes cortisol directly, as well as ACTH, which triggers the production of cortisol.

Magnesium Glycinate 150 mg

Common magnesium supplements have poor absorption in your body. Magnesium glycinate is one of the most bioavailable forms. Unfortunately, most people are magnesium-deficient. Because magnesium has an important role in keeping your parasympathetic nervous system (PNS) healthy, a lack of minerals can manifest as chronic tension, stress, and anxiety. You may find you’re unable to get out of the negative thinking loop, or a stressed state. Supplementing magnesium will mitigate these side effects of deficiency.

Taurine 500 mg 

Taurine is a natural amino acid with important roles in sleep, mood regulation, and energy production. Studies show that supplementing taurine effectively reduces stress. This is due to taurine’s effect on your GABA receptors.

Gamma-aminobutyric acid (GABA) is a crucial neurotransmitter that induces a state of calm and relaxation. But things like stress, injury, and allergies can deplete your GABA levels. To undo the damage done by stress, it’s important to boost GABA. However, supplementing with GABA directly is ineffective because its molecular weight is too large to pass the blood-brain barrier. Therefore, supplementing with GABA precursors – such as taurine – leads to better absorption and increased GABA production in the brain.

Zinc 10 mg

Zinc is one of the keys to a healthy nervous system, and by extension your stress response. Prolonged stress and inflammation both deplete stores of zinc in the body. Because of this, supplementation is an excellent way to return to optimal well-being after chronic stress. Research shows that zinc supplements help re-stabilize cortisol levels.

Chamomile Extract 100 mg

Chamomile is another powerful cortisol-reducer. As such, it directly lowers your stress levels. Chamomile also helps promote restful and restorative sleep by binding to your benzodiazepine brain receptors.


BioPerine® is a patented form of black pepper extract that contains 95% piperine. Piperine is the bioactive compound of black pepper that increases absorption of other ingredients, so you can get the most out of them. Compare this with regular black pepper in your kitchen, which only has 5% piperine, making it ineffective.

Pros and Cons of SRS – The Stress Reduction Supplement


  • Clinically researched by experts in the field.
  • Features a blend of nutrients and herbal remedies to undo the damage from chronic stress.
  • Bolsters your physical and mental stress response, improves sleep, enhances recovery, and improves focus.


  • Only available on the manufacturer’s website.

SRS is Available at

Click Here to Check Price

2. Kurapeak – Best Supplement for Women

Kurapeak is a vitality supplement for women. The same manufacturer has also developed a similar product for men – Centrapeak.

Kurapeak has been formulated to help women with their health, work, and home life. It works to boost your libido & energy, improve focus, and diminish stress & anxiety.


Gone are the days where you’d have to live in Siberia to experience the life-enhancing properties of Ginseng. In today’s world, you can get all of the best plants from across the Earth. Kurapeak contains only the best, most researched ancient medicines. It is made of Panax Ginseng, Pine Bark Extract, L-Theanine, Maca, BioPerine, Rhodiola Rosea, Turmeric, and the world’s most expensive spice – Saffron.

Here we’ll look closer at a few of the ingredients. If you want to see the full breakown of the studies and academic research in each Kurapeak ingredient, you can visit their website:

L-Theanine – 100 mg

L-Theanine is an amino acid found in green tea and certain mushroom species. Studies show that it promotes relaxation without making you drowsy. When taken as a supplement, L-Theanine also aids sleep. In tea, on the other hand, caffeine is also present, which could negate some of the benefits.

Rhodiola Rosea – 100mg

Rhodiola Rosea is an adaptogen that’s been shown to bolster the stress response. It’s been used for hundreds of years to tackle fatigue, stress, and anxiety among others.

Turmeric Curcumin 50:1 200mg

You probably have Tumeric in your kitchen cupboard, but were you aware that Tumeric can boost dopamine and serotonin? This is because of the active ingredients, curcuminoids. However, the Tumeric you put in your curry only has around 5% curcuminoids which means you have to eat a lot to experience the benefits. The Tumeric in Kurapeak, on the other hand, contains 95% curcuminoids!

Turmeric can boost dopamine and serotonin, two key neurotransmitters involved in mood and stress regulation. The active ingredients in turmeric, curcuminoids, are the ones to thank. However, the Turmeric found in your kitchen only has around 5% curcuminoids which means you’d have to eat a ton to experience the benefits. The turmeric in Kurapeak, by contrast, is standardized to have 95% curcuminoids.

A randomized controlled trial showed that depressed people who took curcumin experienced similar improvements in their depression symptoms as with Prozac! The study showed that taking Prozac and curcumin together worked even better.

Panax Ginseng – 120 mg

Ginseng is an adaptogenic her that’s been used since 5,000 years ago! It’s said to boost energy, mental alertness, enhance sex drive, and improve overall well-being. Latest studies confirm Ginseng’s benefits to the health of our brain and nervous system, leading to a reduction in fatigue and anxiety.

Pros and Cons


  • Designed specifically for females.
  • Clinically backed ingredients.
  • Lowers stress & anxiety.
  • Boosts energy and combats fatigue.
  • Enhances libido.
  • Features a blend of ancient medicinal herbs from different parts of the world.


  • Lacking some vitamins and minerals.
  • You can only buy it on the manufacturer’s website.

3. Performance Lab Mind

Performance Lab is an established nutrition company that uses advanced, patented technologies and science-backed ingredients to create innovative and effective supplements.

Mind is a nootropic formulated to optimize your mental performance. It elevates cognition and increases circulation to your brain, improving your focus, mood, and energy levels. By extension, this will help you better manage stress.

We’ve already talked about two of the ingredients in Mind under SRS: Phosphatidylserine (100mg) and Tyrosine (250mg). In addition to these two, Mind also contains:

Citicoline (Cognizin) 250 mg

Cognizin is a Performance Lab-patented form of citicoline. Citicoline has the ability to strengthen memory and learning and also increases attention span. It is also neuroprotective, helping to repair your brain cell membranes and reduce inflammation.

Maritime Pine Bark Extract 75 mg

Pine Bark Extract is an antioxidant that boosts nitric oxide levels while assisting with glucose and oxygen delivery to your brain cells. This process enhances brain and heart function, extinguishes inflammation, balances blood pressure, and improves mood.

Pros and Cons of Mind


  • A nootropic that supports all-around brain health.
  • Enhances learning capacity, focus, memory, and energy levels.
  • Recover faster after stress.
  • Tackles symptoms linked to stress, such as fatigue and weak cognitive reasoning.


  • Not specifically designed for stress or anxiety.
  • It can only be bought on the manufacturer’s website.

Anything Else to Consider?

Supplements are an excellent aid that can help lower your stress and anxiety symptoms. However, by having the right foundations – diet, exercise, relaxation time – you will naturally deal with stress better, and the effects of these supplements will be enhanced.

Here are some of the basic lifestyle habits you should stick to to ensure you get the most out of the aforementioned stress supplements:

  • Aerobic and resistance training – Exercise releases dopamine and serotonin which focus your mind, distract you from worries, and make you feel good. Even a quick walk can make a massive difference. If you can find someone to exercise with, even better.
  • Mindfulness and meditation – Mindfulness is all about being in the present moment. At first, this can be really hard, as our mind likes to wonder a lot, which keeps us stressed. Luckily, doing meditation consistently is just like any skill – it improves over time, and you start to feel more relaxed and at ease. You start to see the thoughts for what they are, and they begin to lessen in frequency and intensity.
  • Diet – What you eat fuels both your body and mind. Your gut, where over 90% of your serotonin resides, is directly connected to your brain. A diet high in processed foods can be detrimental to your gut microbiome, negatively affecting your mood in the process.
  • Sleep – This is arguably the most important item on the list. Sleep impacts everything from hormone production, energy, mood, and motivation. Lack of sleep can burn out your adrenal glands, which has the biggest impact on chronic stress. Having a healthy sleep schedule keeps your body nourished, and your mind calm.

When you add a quality stress relief supplement on top of these lifestyle habits, you will see the best results. Here are some common questions about stress relief supplements answered:

Can an anti-stress supplement improve my mental health?

This is easy to forget (or ignore), but it’s important that you speak to your doctor before taking any supplement – especially if you have any sort of condition. Never come off prescription drugs before talking to your physician first. People with certain problems can sometimes find relief in food supplements like the ones we’ve listed here, but everyone is different. Remember that our posts aren’t meant as medical advice; they’re for informational and entertainment purposes only!

Will taking supplements have any side effects?

We’ve only shown you the highest-quality supplements in this guide. All of the supplements you’ve seen here are completely natural, with no hidden ingredients. As long as you stick to the dosage recommendations, you shouldn’t experience any negative side effects. Again, as we said, if you suspect a supplement might not be right for you, always check with your doctor before taking it.

Conclusion on the Best Over the Counter (OTC) Supplements for Stress

So there you have it, these are currently the best-reviewed stress relief supplements for 2022.

The most effective supplement to reduce stress at the moment, in our experience, is SRS. It’s got most of our favorite ingredients and they are clinically dosed.

That being said, Kurapeak and Mind are also great options. Kurapeak, for women – it enhances mood, well-being, and female health & vitality in general. Mind is the superior option if you’re looking for a memory and focus nootropic.

If you’re looking improved sleep, focus, and stress response, giving you the ability to make long-lasting changes in your life, our top choice remains SRS.

To finish this off with one final note: supplements are only half the battle. To experience the most profound change, you need to have good habits in place as well. If you’ve tried supplements and nothing helps, remember to speak to a qualified professional about other options which may be helpful for your specific situation

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