Best OTC Stress Relief Supplements in 2024

Best OTC Stress Relief Supplements

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Looking to feel calmer, with less stress and anxiety? Here are our top 2 recommended over-the-counter stress relief supplements. If you already aren’t familiar with them, so-called non-prescription stress relief supplements are designed to support your mood and relaxation by reducing cortisol levels, calming neurotransmitters linked to anxiety, and promoting brain chemicals such as GABA which calm your mind down.

We’ve developed a list of criteria that enables us to weed out ineffective (and potentially risky) products from ones that are safe and natural. These include:

  • Evidence-backed ingredients
  • Safe & effective dosages backed by studies
  • Brand reputation

The following non-prescription stress relief supplements also have the ability to improve your mental and physical recovery by enhancing your sleep, which will have a positive knock-on effect on other areas of your life.

There aren’t that many good stress relief supplements on the market today compared to other products like nootropics or joint supplements. For this reason, we’ve decided to only include two of what we consider to be the best stress relief supplements you can find right now.


• 100% natural & transparent

• Researched and fact-checked by doctors

• Relieves stress & anxiety

• Supports recovery from burnout

• Clinically dosed herbal medicines inside

• Bulk-buy deals
• Website:


• Our #1 OTC Anti-Anxiety Choice

• Made with science-backed ingredients
• Improves stress response
• Enhances mood & cognitive function
• Healthy for everyday use

• Website:


• 4 generously dosed nootropics

• Works to enhance all aspects of brain function
• Uses patented nutrition technologies

• Made by a well-known company, Opti-Nutra
• Website:

The Best OTC Stress Relief Supplements of 2024

Let’s look at our current top 2 supplements to improve your body’s stress response and enhance your overall well-being.

  • #1 Best Overall Over-the-Counter Stress Relief Product: Xanapril
  • #2 Best for Cognitive Performance & Well-Being – Performance Lab Mind

1. Xanapril – The Best OTC Stress Relief Supplement


Our top pick is Xanapril, a natural over-the-counter anti-stress formula. It stands out for its study-backed ingredients in effective dosages. Xanapril should be safe for most people looking to relieve anxiety, insomnia, and restless thoughts without side effects of pharmaceutical drugs.

Xanapril isn’t trying hard to be something it’s not; what you see on the ingredient label is what you get. Not only does it benefit your cognitive resilience to stress, but it’s also fully transparent. You know exactly what, and how much, you’re putting in your body.

Benefits that you may experience using Xanapril include:

  • Reduced Anxiety and Stress: helping you to navigate day and conversations with people.
  • Healthy Mental Focus & Clarity: combating cognitive fatigue for sustained mood throughout the day.
  • Sharper Focus: Enhance your productivity and creativity without overthinking.
  • Deeper sleep: Some ingredients in Xanapril are shown to improve sleep quality, which could mean more energized and refreshing mornings.
  • Emotional Stability: Xanapril’s ingredients may help to brighten your mood & positive thinking throughout the day.
  • Safe for Daily Use: Xanapril’s gentle anti-anxiety and mood-enhancing effects come without the risk of addiction or withdrawals.


  • 1-Month Supply: $69.00 for 90 Capsules
  • 2-Month Supply: $138.00 for 180 Capsules
  • 3-Month Supply: $207.00 for 270 Capsules

Click to Get Xanapril Prices

Ingredients in Xanapril

  • Magnesium (As Magnesium L-Threonate): 16.5mg (4% DV)
  • Ashwagandha (Withania somnifera) (Root) (std. to 5% Withanolides): 500mg
  • Gamma-Aminobutyric Acid (GABA): 500mg
  • Korean Ginseng Extract (Panax Ginseng)(Root): 400mg
  • Rhodiola Rosea Extract (std. to 3% Salidrosides): 200mg

Xanapril doesn’t overcomplicate with the ingredients. Each one has its role in the formula and synergy with other ingredients. Ashwagandha, for example, lowers your cortisol levels, which leads to reduced feelings of stress and tension. Korean Ginseng promotes mental energy and focus. Rhodiola Rosea fights fatigue, improves blood sugar levels for more stable energy, and bolsters your resilience to stress, especially when you need to face challenges or process a lot of information in a short period of time.

Pros of Xanapril:

  • Science-backed, natural ingredients
  • Supports brain function, mood, and sleep
  • Safe for daily use
  • Mildly to moderately efffective for stress and anxiety management

Cons of Xanapril:

2. Performance Lab Mind

Performance Lab (Opti-Nutra) is a respected nutrition company from the U.K. They use advanced, patented technologies to develop some of the cleanest-quality supplements on the market.

Mind is a nootropic/brain supplement that is designed to naturally elevate your cognitive performance. At first glance, its 4-ingredient formula may look simple. However, the quality and dosages of the ingredients used in Mind far outperform most supplements on offer today.

Almost all the ingredients in Performance Lab Mind come in patented versions, standardized to have a precise amount of active compounds for maximum effect on your brain function.

Two key ingredients in Mind that are shown to reduce stress and promote calm thoughts (especially under pressure or during mentally demanding situations) are Phosphatidylserine (100mg) and Tyrosine (250mg). In addition to these two, Mind also contains:

Citicoline (Cognizin) 250 mg

Cognizin is a highly bioavailable form of citicoline patented by Performance Lab. Citicoline supports the brain’s circuits and the production of acetylcholine which strengthens your memory and learning and also enhances your attention span. Citicoline is also neuroprotective and reduces inflammation in the brain.

Maritime Pine Bark Extract 75 mg

Native to France, the bark of the French Maritime Pine tree has high amounts of antioxidants – known as proanthocyanidins – which are shown to increase blood circulation to the brain. In doing so, they promote increased brain function, bright mood, and balanced blood pressure to name a few.

Pros and Cons of Mind


  • Streamlined formula – 4 generously dosed nootropics for healthy and safe daily use
  • Improves your learning capacity, memory retention, focus maintenance, and energy levels
  • Helps your mind to recover quickly after stress
  • Helps with symptoms linked to stress, such as mental fatigue and brain fog


  • Not specifically formulated for stress and anxiety, but for all-around brain health
  • It can only be bought on the manufacturer’s website.

Anything Else to Consider?

Supplements are an excellent aid that can help lower your stress and anxiety symptoms. However, by having the right foundations – diet, exercise, relaxation time – you will naturally deal with stress better, and the effects of these supplements will be enhanced.

Here are some basic lifestyle habits you can implement to get the most out of anti-stress supplements:

  • Aerobic and resistance training – Exercise releases dopamine and serotonin which focus your mind, distract you from worries, and make you feel good. Even a quick walk can make a massive difference. If you can find someone to exercise with, even better.
  • Diet – What you eat fuels both your body and mind. Your gut, where over 90% of your serotonin resides, is directly connected to your brain. A diet high in processed foods can be detrimental to your gut microbiome, negatively affecting your mood in the process.
  • Sleep – This is arguably the most important item on the list. Sleep impacts everything from hormone production, energy, mood, and motivation. Lack of sleep can burn out your adrenal glands, which has the biggest impact on chronic stress. A healthy sleep schedule keeps your body nourished, and your mind calm.

When you add a quality stress relief supplement on top of these lifestyle habits, you are going to see the best results.

Conclusion on the Best Over the Counter (OTC) Supplements for Stress

So there you have it, these are currently the best-reviewed stress relief supplements for 2024.

The top rated stress relief supplement from our analysis here is Xanapril. It has most of our favorite ingredients which are clinically dosed.

Mind is also an effective option if you want not just better mood but also increased productivity, improved memory, and protection of long-range brain function.

Lastly, and we cannot emphasize this enough: supplements are only a part of the battle. To experience the most profound change, you need to have good habits in place as well. If you’ve tried supplements and nothing helps, remember to speak to a qualified professional about other options which may be helpful for your specific situation.

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